5-MTHF 1mg
Bioavailable folate for methylation, pregnancy support, and cellular health.
Thorne 5-MTHF 1 mg delivers the active, methylated form of folate your body can use immediately—supporting methylation, heart and brain health, and healthy fetal development. Unlike standard folic acid, 5-MTHF bypasses common genetic limitations (like MTHFR variations), making it especially beneficial for individuals who have difficulty converting folic acid into its usable form.
This essential nutrient plays a key role in mood balance, energy production, detoxification, and cellular function, while also providing critical support during pregnancy. With a clean, highly absorbable formula in small, easy-to-take capsules, it’s a simple way to ensure optimal folate levels for overall wellness.
Benefits of Thorne’s 5-MTHF:
- Nutritional support for individuals who have an MTHFR gene mutation
- Supports production of key neurotransmitters – serotonin, melatonin, dopamine, and epinephrine – natural brain chemicals that play an important role in regulating brain function and mood
- Promotes cardiovascular, brain, and bone health by maintaining a healthy methylation cycle and a normal homocysteine level
- Supports healthy fetal brain and spinal cord development
- Promotes blood and nerve cell health
Take 1 capsule one to two times daily or as recommended by your health-care practitioner.
ALLERGY WARNING: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY: If pregnant, consult your health-care practitioner before using this product.
INTERACTIONS: 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate’s anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
Ingredient Amounts
Serving Size: 1 Capsules
Servings Per Container: 60
- Folate (L-5-MTHF) 8.3mg DFE
- Other Ingredients: Hypromellose Capsule, Leucine, Microcrystalline Cellulose, Silicon Dioxide
Testing: This product has been third-party tested and certified to verify what’s in the package matches what’s on the label and to confirm it contains no unsafe levels of contaminants, such as heavy metals, pesticides, and microorganisms
cGMP Certified: Good Manufacturing Practices (cGMP)
NSF certified: Thorne’s facility is National Sanitation Foundation (NSF) certified
TGA Certified: Thorne has an A rating from Australia’s Therapeutic Goods Administration (TGA)






